Insect leg development
Evolution out on a limb
by Pierre Jerlstrom
April 1, 2001
Featured In
Hidden unity
The body plans of vertebrates and
insects differ greatly in their size and shape, and in
the type and number of appendages. Nevertheless, there
is a hidden unity in the genes and the genetic system
that control their development. Cells along the main
body axis of vertebrates, and of insects such as fruit
flies, ‘know’ their position as well as what type of
appendage they will develop into from the level of
expression of the homeotic selector genes (Hox) inside
their nuclei.1
The role of specific Hox genes in insect
limb development has recently been studied. At a certain
stage of insect larva growth the Distal-less (Dll)
gene switches on, causing some of its cells to organize
into legs. Switching off Dll on the other hand,
results in only stumps forming.2 In the early
1990s, scientists were astounded to find almost
identical copies of this gene in vertebrates, and to
find that as with insects, these genes switch on during
leg development. This was surprising because vertebrates
and insects have completely different limbs: bugs have
their muscles on the inside of a protective exoskeleton,
whereas in animals muscle covers the bone. And,
according to evolutionary belief, insects and
vertebrates are only distantly related to a limbless
flatworm that lived perhaps a billion years ago. They
believe that limbs and the genes for their development
have evolved independently in these two lineages.2
Scientists further looked at other
‘distant relatives’ of the flatworm such as velvet
worms, sea urchins and sea squirts, which also have
limb-like appendages. They found that Dll-like
genes were active in the developing appendages in each
of these animals.2
Looking at the evidence within a
Biblical framework, it is easy to recognise this hidden
unity in limb development as the work of one Creator who
used a highly successful, basic blueprint to design
appendages for movement for the various created kinds.
By analogy, the wheels of bicycles, cars, trains, etc.,
have not arisen by accident, but are all variants of a
basic engineering design. In this light, it is not
surprising to find that similar molecular information
(Hox genes) in the genetic code of different animals
gives rise to analogous leg structures.
Mutant study
Two other Hox genes, Ultrabithorax
(Ubx) and abdominal-A (abd-A), also
have distinct functions in some insects. In the red
flour beetle, Tribolium castaneum, abd-A
determines whether or not a limb grows in the abdomen by
acting on Dll, while Ubx tells the cells
what type of limb they should become.3,4 When
scientists inactivated these two genes they found that
flour beetle larvae sprouted 16 legs on their abdomen.
This has been hailed as supporting evidence for the idea
that insects and arthropods (animals without backbones)
evolved 400 million years ago from animals resembling
centipedes and millipedes, which have many
non-specialized body segments, each with its own pair of
legs. During the supposed evolution of insects, groups
of segments fused together to form the head, the thorax
and a legless abdomen. Leg-making genes also switched
off, giving rise to more agile six-legged insects.4,5
Although a beetle larva can be persuaded
to produce legs on its abdomen, this is hardly support
for evolution. It only confirms the role of particular
genes in leg development—it is well known that in
insects every segment has the potential to form a limb.5
But the type of limb, or whether or not it forms, is
determined by the individual Hox genes—in the fruit fly
Drosophila melanogaster, a particular appendage
(leg type or antenna) in a segment is specified by a
pair of Hox genes.
Conclusion
Even the idea of mere insect evolution
is inconsistent. Evolutionists are perplexed as to how
evolution could have produced such huge morphological
variation among insects, especially considering how
highly conserved Hox gene expression is within this
lineage.3 The Scriptures plainly describe
that all creeping things, which includes insects, were
created complete on the same 6th Day of
Creation to multiply after their own kind.
Evolutionary dogma interprets similarity
as phylogeny. The genome of the fruit fly Drosophila
has recently been sequenced.6 With the
elucidation of the complete DNA sequence of more insects
in the future, the lack of phylogeny will become clearly
evident, as has been recently documented among
microorganisms.7,8 This will result in the
further collapse of the ailing evolutionary ‘tree of
life’, as insects believed to be lower or higher in the
tree are seen not to be connected by consistent lines of
descent. One wonders whether multiple origins of insects
(‘Creationist orchard’ again) will also be proposed as
this unfolds.8
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Insect leg
development: Evolution out on a limb by
Pierre Jerlstrom
Featured In
Hidden unity
The body plans of vertebrates and insects differ
greatly in their size and shape, and in the type and
number of appendages. Nevertheless, there is a hidden
unity in the genes and the genetic system that control
their development. Cells along the main body axis of
vertebrates, and of insects such as fruit flies, ‘know’
their position as well as what type of appendage they
will develop into from the level of expression of the
homeotic selector genes (Hox) inside their nuclei.1
The role of specific Hox genes in insect limb
development has recently been studied. At a certain
stage of insect larva growth the Distal-less (Dll)
gene switches on, causing some of its cells to organize
into legs. Switching off Dll on the other hand,
results in only stumps forming.2 In the early
1990s, scientists were astounded to find almost
identical copies of this gene in vertebrates, and to
find that as with insects, these genes switch on during
leg development. This was surprising because vertebrates
and insects have completely different limbs: bugs have
their muscles on the inside of a protective exoskeleton,
whereas in animals muscle covers the bone. And,
according to evolutionary belief, insects and
vertebrates are only distantly related to a limbless
flatworm that lived perhaps a billion years ago. They
believe that limbs and the genes for their development
have evolved independently in these two lineages.2
Scientists further looked at other ‘distant
relatives’ of the flatworm such as velvet worms, sea
urchins and sea squirts, which also have limb-like
appendages. They found that Dll-like genes were
active in the developing appendages in each of these
animals.2
Looking at the evidence within a Biblical framework,
it is easy to recognise this hidden unity in limb
development as the work of one Creator who used a highly
successful, basic blueprint to design appendages for
movement for the various created kinds. By analogy, the
wheels of bicycles, cars, trains, etc., have not arisen
by accident, but are all variants of a basic engineering
design. In this light, it is not surprising to find that
similar molecular information (Hox genes) in the genetic
code of different animals gives rise to analogous leg
structures.
Mutant study
Two other Hox genes, Ultrabithorax (Ubx)
and abdominal-A (abd-A), also have
distinct functions in some insects. In the red flour
beetle, Tribolium castaneum, abd-A
determines whether or not a limb grows in the abdomen by
acting on Dll, while Ubx tells the cells
what type of limb they should become.3,4 When
scientists inactivated these two genes they found that
flour beetle larvae sprouted 16 legs on their abdomen.
This has been hailed as supporting evidence for the idea
that insects and arthropods (animals without backbones)
evolved 400 million years ago from animals resembling
centipedes and millipedes, which have many
non-specialized body segments, each with its own pair of
legs. During the supposed evolution of insects, groups
of segments fused together to form the head, the thorax
and a legless abdomen. Leg-making genes also switched
off, giving rise to more agile six-legged insects.4,5
Although a beetle larva can be persuaded to produce
legs on its abdomen, this is hardly support for
evolution. It only confirms the role of particular genes
in leg development—it is well known that in insects
every segment has the potential to form a limb.5
But the type of limb, or whether or not it forms, is
determined by the individual Hox genes—in the fruit fly
Drosophila melanogaster, a particular appendage
(leg type or antenna) in a segment is specified by a
pair of Hox genes.
Conclusion
Even the idea of mere insect evolution is
inconsistent. Evolutionists are perplexed as to how
evolution could have produced such huge morphological
variation among insects, especially considering how
highly conserved Hox gene expression is within this
lineage.3 The Scriptures plainly describe
that all creeping things, which includes insects, were
created complete on the same 6th Day of
Creation to multiply after their own kind.
Evolutionary dogma interprets similarity as
phylogeny. The genome of the fruit fly Drosophila
has recently been sequenced.6 With the
elucidation of the complete DNA sequence of more insects
in the future, the lack of phylogeny will become clearly
evident, as has been recently documented among
microorganisms.7,8 This will result in the
further collapse of the ailing evolutionary ‘tree of
life’, as insects believed to be lower or higher in the
tree are seen not to be connected by consistent lines of
descent. One wonders whether multiple origins of insects
(‘Creationist orchard’ again) will also be proposed as
this unfolds.8
http://www.answersingenesis.org/articles/tj/v15/n1/insect