Is bacterial resistance to antibiotics an appropriate example of evolutionary change?

[Is bacterial resistance to antibiotics an appropriate example of evolutionary change? Kevin Anderson, Ph.D.]  "[Summary quoted directly from the actual paper] "[Summary]...Resistance to antibiotics and other antimicrobials is often claimed to be a clear demonstration of “evolution in a Petri dish.” However, analysis of the genetic events causing this resistance reveals that they are not consistent with the genetic events necessary for evolution (defined as common “descent with modification”). Rather, resistance resulting from horizontal gene transfer merely provides a mechanism for transferring pre-existing resistance genes. Horizontal transfer does not provide a mechanism  for the origin of those genes. Spontaneous mutation does provide a potential genetic mechanism for the origin of these genes, but such an origin has never been demonstrated. Instead, all known examples of antibiotic resistance via mutation are inconsistent with the genetic requirements of evolution. These mutations result in the loss of pre-existing cellular systems/activities, such as porins and other transport systems, regulatory systems, enzyme activity, and protein binding. Antibiotic resistance may also impart some decrease of “relative fitness” (severe in a few cases), although for many mutants this is compensated by reversion. The real biological cost, though, is loss of pre-existing systems and activities. Such losses are never compensated, unless resistance is lost, and cannot validly be offered as examples of true evolutionary change." Is bacterial resistance to antibiotics an appropriate example of evolutionary change? Anderson, Is Bacterial Resistance to Antibiotics an Appropriate Example of Evolutionary Change?

Is bacterial resistance to antibiotics an appropriate example of evolutionary change?