PRONOUNCEMENT OF JUDGMENT ON THOSE WHO RECEIVE THE MARK OF THE BEAST
It is probably true that those who live through all or most of the Great Tribulation do so because they had received the mark of the Beast. However, part of the Great Tribulation is not caused by Satan’s being released but by Christ’s judgment upon this earth. He will move personally and directly in putting down the rebellion against Him here on this earth.
And the third angel followed them, saying with a loud voice, If any man worship the beast and his image, and receive his mark in his forehead, or in his hand,
The same shall drink of the wine of the wrath of God, which is poured out without mixture into the cup of his indignation; and he shall be tormented with fire and brimstone in the presence of the holy angels, and in the presence of the Lamb:
And the smoke of their torment ascendeth up for ever and ever: and they have no rest day nor night, who worship the beast and his image, and whosoever receiveth the mark of his name.
Here is the patience of the saints: here are they that keep the commandments of God, and the faith of Jesus [Rev. 14:9–12].
And another angel, a third, followed them, saying with a great voice, If any man worshippeth the beast and his image, and receiveth a mark on his forehead, or upon his hand, he also shall drink of the wine of the wrath of God, which is mingled unmixed in the cup of His anger; and he shall be tormented with fire and brimstone in the presence of the holy angels, and in the presence of the Lamb; and the smoke of their torment goeth up for ever and ever (unto the ages of the ages); and they have no rest day and night, they that worship the wild beast and his image, and whoso receiveth the mark of his name. Here is the patience of the saints, who keep the commandments of God and the faith of Jesus.
He is speaking to a group of people who “keep the commandments of God,” the Old Testament law. Scripture tells us that sacrifices will be brought during the Great Tribulation and even into the Millennium.
This section makes it crystal clear that no one can assume a neutral position during this intense period under the Beast. Even today we see Christian businessmen who are capitulating to the ethics of the hour. In chapter 13 we saw that the awful alternative for refusing to receive the mark of the Beast was starvation. On the other hand, the person who receives the mark brings down upon his head the wrath of God.
“He also shall drink of the wine of the wrath of God.” If you believe that the church is going through the Great Tribulation, you also believe that the Lord Jesus Christ is going to subject His own to the mingled, unmixed cup of His anger. I simply cannot believe that Christ would do this to the church which He has redeemed.
“The wine of the wrath of God” is a figure adopted from the Old Testament. In Psalm 75:8 we read: “For in the hand of the Lord there is a cup, and the wine is red; it is full of mixture; and he poureth out of the same: but the dregs thereof, all the wicked of the earth shall wring them out, and drink them.” The Old Testament prophets picked up that theme. They saw the cup of wrath filling up to the brim. God was patient and let man go on and on in his sin, but when the cup of wrath was filled, then God would press it to the lips of a godless society. Rebellious men kept building this thing up until judgment had to break.
“Tormented with fire and brimstone.” Now let me say that if this is not literal fire and brimstone, whatever it is must be worse than fire and brimstone. If it is a symbol, remember that a symbol is used to give a faint representation of the real. It is rather like the essence of something. There is the essence of pepper and the essence of perfume. Essence is the faint odor that is left in the bottle after the substance is gone. A symbol is an essence or just a faint copy of the real thing, and the reality can be much worse than the symbol indicates. But remember, the brimstone of Sodom was quite literal. That is a fact you should mull over in your mind if you want to reject a literal hell.
You will notice in this passage that hell is visible to Christ and the holy angels. It does not say that hell is visible to the twenty-four elders. Are we to assume from that that the church does not know what is taking place on the earth? I am inclined to believe that the church will not see what is taking place on the earth during the Great Tribulation Period, but certainly Christ and the holy angels will see it.
All that God’s own can do during this period is to be patient and wait for the coming of Christ. Our Lord said: “But he that shall endure unto the end, the same shall be saved” (Matt. 24:13). Why will he endure? He will endure because he has been sealed by the Spirit of God, and he is clothed in the righteousness of Christ. He is able to overcome by the blood of the Lamb. Our Lord said, “In your patience possess ye your souls?” (Luke 21:19). All they can do is wait out the storm, and that is what they will do during the Great Tribulation.
McGee, J. Vernon: Thru the Bible Commentary. electronic ed. Nashville : Thomas Nelson, 1997, c1981, S. 5:1009-1010

13:16 a mark. In the Roman Empire, this was a normal identifying symbol, or brand, that slaves and soldiers bore on their bodies. Some of the ancient mystical cults delighted in such tattoos, which identified members with a form of worship. Antichrist will have a similar requirement, one that will need to be visible on the hand or forehead.

MacArthur, John Jr: The MacArthur Study Bible. electronic ed. Nashville : Word Pub., 1997, c1997, S. Re 13:16