And I looked, and behold a pale horse: and his name that sat on him was Death, and Hell followed with him. And power was given unto them over the fourth part of the earth, to kill with sword, and with hunger, and with death, and with the beasts of the earth [Rev. 6:7–8].


And when He had opened the fourth seal, I heard the voice of the fourth living creature saying, Go. And I looked and behold a pale (greenish–yellow) horse; and the one sitting upon him, Death was his name; and Hades followed with him. And there was given unto them authority over the fourth part of the earth, to kill with the sword, and with famine, and with death (pestilence), and by the (wild) beasts of the earth.

Here is a pestilence that is going to take out one–fourth of the population of the earth. There will not be enough antibiotics and penicillin to go around in that day to stop it.
“Death was his name.” Death is no more personalized here than is war—although the rider is given the name of death. There is more involved in physical death than meets the eye, for the human being is more than physical, and death is more than cessation of physical activity. While death takes the body, hades is the place where the spirit of a lost man goes (see Luke 16:23, ASV).
A literal translation of Romans 5:14 reads thus: “And nevertheless death became king from Adam down to Moses, even over them who did not sin after the fashion of Adam’s sin [transgression] who is the type of Him [The Adam] who was to come [The Coming One].”
“Death was his name; and Hades followed with him.” The word for hades is sometimes unfortunately translated by the word hell as in Luke 16:23 where, speaking of the rich man and Lazarus, we read: “And in hell he lift up his eyes, being in torments, and seeth Abraham afar off, and Lazarus in his bosom.” Hell is a very unfortunate translation there; it is this same word hades, and actually, it does not refer to hell at all. It speaks of physical death—either where the spirit goes or of the grave where the body is placed. In other words, while death takes the body, hades is the place where the spirit of a lost man goes. The Lord Jesus spoke of it in that way.
Paul personifies death in Romans 5:14, as he does sin in that same section, and he does it for emphasis. Sin and death entered the world at the same time. Death is the result of sin. During the interval from Adam to Moses, men did not commit the same sin as did Adam, nor was their sinning a transgression of a law, as was Adam’s, because the Ten Commandments had not been given. Yet it was a period when men sinned and died. Adam’s sin became their sin, for they died as Adam died. Even babies died in the Flood.
Death evidently has an all–inclusive, three–fold meaning that we do not ordinarily attach to it. We think of death as referring only to the body. (1) This is physical death, and it refers only to the body. It comes to a man because of Adam’s sin. (2) Then there is what is known as spiritual death, which is separation from, and rebellion against, God. We inherit a dead nature from Adam; that is, we have no capacity for God and no desire for Him at all. (3) Finally, there is eternal death, which is eternal separation from God. Unless a man is redeemed, this inevitably follows. This is the second death that we will find later on in chapter 20, verse 14.
Before Adam sinned, God said to him, “… for in the day that thou eatest thereof thou shalt surely die” (Gen. 2:17). Well, Adam lived physically for more than nine hundred years after that, but he was dead spiritually to God. He ran from God. He no longer had a desire for fellowship with God. He died spiritually, and physical death followed and has come into the human family. More and more it deteriorates mankind. Most of us are being propped up today by modern medicine and the marvelous developments of science in order to stay alive. Actually, the human race is deteriorating all the time. Human life would be much shorter than it is if it were not for all the modern gadgets which keep us alive down here.
Adam is definitely declared here to be a type of Christ. Death must be laid at Adam’s door as his total responsibility. You see, God did not create man to die. It was a penalty imposed because Adam transgressed God’s command. Because Adam is the federal head of our race, his transgression is our transgression, and his death is our death. Now Christ is the head of a new creation, and this new creation has life only in Christ. He alone can give life. He is totally responsible for the life and eternal bliss of those who are His own.
Dr. Lewis Sperry Chafer put it like this, and this is a theological statement:

Thus spiritual death comes mediately through an unbroken line of posterity. Over against this, physical death is received from Adam immediately, as each person dies in body because of his own personal share in Adam’s first sin.

During the Great Tribulation, death will ride unbridled. The Lord Jesus put it like this: “And except those days should be shortened, there should no flesh be saved: but for the elect’s sake those days shall be shortened” (Matt. 24:22).
At the Great White Throne judgment, death will be finally destroyed (see Rev. 20:14). This is confirmed by Paul who writes, “The last enemy that shall be destroyed is death” (1 Cor. 15:26). And John reasserts it in Revelation 21:4: “And God shall wipe away all tears from their eyes; and there shall be no more death, neither sorrow, nor crying, neither shall there be any more pain: for the former things are passed away.”
The sword, famine, pestilence, and wild beasts will decimate this earth’s population by one–fourth. This is something that, through His prophet Ezekiel, God had said would come: “For thus saith the Lord GOD; How much more when I send my four sore judgments upon Jerusalem, the sword, and the famine, and the noisome beast, and the pestilence, to cut off from it man and beast?” (Ezek. 14:21).
The pale horse represents plague and pestilence that will stalk the earth. It also encompasses the possibility of germ warfare. Dr. Frank Holtman, head of the University of Tennessee’s bacteriological department, said, “While the greater part of a city’s population could be destroyed by an atomic bomb, the bacteria method might easily wipe out the entire population within a week.”
We have seen the riding of the four horsemen, and this follows exactly the pattern that the Lord Jesus gave while He was on the earth. In Matthew 24:5–8, in the Olivet Discourse, He said: “For many shall come in my name, saying, I am Christ; and shall deceive many [the white horse]. And ye shall hear of wars and rumours of wars [the red horse]: see that ye be not troubled: for all these must come to pass, but the end is not yet. For nation shall rise against nation, and kingdom against kingdom: and there shall be famines [the black horse], and pestilences [the pale horse], and earthquakes, in divers places. All these are the beginning of sorrows.” This is the opening of the Great Tribulation.  McGee, J. V. (1991). Thru the Bible commentary: The Prophecy (Revelation 6-13) (electronic ed., Vol. 59, pp. 45–48). Nashville: Thomas Nelson.

Re 6:8 pale horse.“Pale,” the Gr. word from which the Eng. word “chlorophyll” comes, describes the pale, ashen-green, pallor characteristic of the decomposition of a corpse. God grants this horseman the authority to bring death to 25 percent of the world’s population. Hades. See note on Luke 16:23. The place of the dead, which is identified as a common and fitting partner for death (20:13; see note on 1:18).  MacArthur, J., Jr. (Ed.). (1997). The MacArthur Study Bible (electronic ed., p. 2000). Nashville, TN: Word Pub.